2006 ~ 2010

61. Smart Drug-Loaded Polymer Gold Nanoshells for Systemic and Localized Therapy of Human Epithelial Cancer

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author J. Yang, J. Lee, J. Kang, S.-J. Oh, H.-J. Ko, J. -H. Son, K. Lee, J.-S. Suh, Y.-M. Huh, and S. Haam
journal Adv. Mater., 2009, 43, 4339
link http://onlinelibrary.wiley.com/doi/10.10...4/abstract
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Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer drug-loaded polymeric nanoparticles) for systemic chemotherapy of human epithelial cancer and a polymer-based gold nanoshell for localized photothermal treatment by NIR light.


  1. 67. Quantitative catalyst-substrate association relationships between metathesis molybdenum and ruthenium carbene complexes and their substrates

    K. H. Kim, T. Ok, K. Lee, H.-S. Lee, K. T. Chang, H. Ihee, J.-H. Sohn
    J. Am. Chem. Soc., 2010, 132, 12027
    Herein we present the long-sought quantitative catalyst−substrate association relationships based on experimentally measured quantitative association preferences of diverse metathesis Mo and Ru catalysts (Mo-1, Schrock Mo; Mo-2, S...
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  2. 66. Pd-nanoparticle-catalyzed conversion of Fe nanoparticles into diameter- and length-controlled Fe2P nanorods

    H. Kim, Y. Chae, D. H. Lee, M. Kim, J. Huh, Y. KIm, H. Kim, H. J. Kim, S. O. Kim, H. S. Baik, K. Choi, J. S. Kim, G.-R. Yi, K. Lee
    Angew. Chem. Int. Ed., 2010, 49, 5712
    Playing a dual role as a catalyst that destabilizes Fe nanoparticles to form soluble precursors in situ and as a catalytic center for nanorod growth allows Pd nanoparticles to transform Fe nanoparticles and a P source into Fe2P na...
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  3. 65. Activatable nanomaterials in forefront biomedical sciences

    T. Kim, Y.-M. Huh, S. Haam, K. Lee
    J. Mater. Chem., 2010, 20, 8194 (Feature Article)
    This feature article reviews the emerging applications of activatable nanomaterials in the bio- and medical fields, namely, molecular imaging, theragnostics, cancer therapy, tissue engineering, and biosensors. Nanomaterials, with ...
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    64. Ultra-specific enrichment of GST-tagged protein by GSH-modified nanoparticles

    Y.-J. Lee, J.-M. Park, J. Huh, M. Kim, J.-S. Lee, A. Palani, K. Lee, S.-W. Lee
    Bull. Kor. Chem. Soc., 2010, 31, 1568
    The selective isolation of specific proteins from complex protein mixtures by nanoparticles is reported. Glutathionemodified superparamagnetic nanoparticles were used to purify specific proteins fused with glutathione S-transferase via enz...
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  5. 63. Catalytic Nanoparticles Being Facet-Controlled

    K. Lee, M. Kim, H. Kim
    J. Mater. Chem., 2010, 20, 3791 (Invited Highlight Article, Selected as top ten most downloaded J. Mater. Chem. articles in 2010 May)
    The catalytic properties of nanoparticles are determined by the nature of nanoparticle surface. Thus facet-controlled synthesis of catalytic nanoparticles is of paramount importance for both reactive and selective catalysis, an...
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  6. 62. Fast Catalytic and Electrocatalytic Oxidation of Sodium Borohydride on Palladium Nanoparticles and Its Application to Ultrasensitive DNA Detection

    J. Das, H. Kim, K. Jo, K. H. Park, S. Jon, K. Lee, H. Yang
    Chem. Commun., 2009, 6394
    We report an ultrasensitive DNA sensor using the rapid enhancement of electrocatalytic activity of DNA-conjugated Pd nanoparticles (NPs); the rapid enhancement results from the fast catalytichydrolysis of NaBH4 on Pd NPs and subsequ...
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  7. 61. Smart Drug-Loaded Polymer Gold Nanoshells for Systemic and Localized Therapy of Human Epithelial Cancer

    J. Yang, J. Lee, J. Kang, S.-J. Oh, H.-J. Ko, J. -H. Son, K. Lee, J.-S. Suh, Y.-M. Huh, and S. Haam
    Adv. Mater., 2009, 43, 4339
    Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer drug-loaded polymeric nanoparticl...
    Read More
  8. 60. Surface-modified Nafion membrane by trioctylphosphine-stabilized palladium nanoparticles for DMFC applications

    A. H. Tian, J.-Y. Kim, J. Y. Shi, K. Lee, K. Kim
    J. Phys. Chem. Solids., 2009, 70, 1207
    Trioctylphosphine (TOP)/Pd composites have been synthesized and used as a methanol-barrier material to modify the surface of Nafion 115. The TOP/Pd composites have been applied to the surface of Nafion instead of being incorporated i...
    Read More
  9. 59. High-Mobility Anthracene-based X-shaped Conjugated Molecules for Thin Film transistors

    K. H. Jung, S. Y. Bae, K. H. Kim, M. J. Cho, K. Lee, Z. H. Kim, D. H. Choi, D. H. Lee, D. S. Chung, C. E. Park
    Chem. Commun., 2009, 5290
    New anthracene-based X-shaped conjugated molecules 1 and 2 for use as highly soluble p-type organic semiconductors were developed and exhibited large field-effect mobilities of 0.04 cm2V−1 s−1 (Ion/Ioff = 2.8 × 105) and 0.24 cm2V−...
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  10. 58. Antibiofouling, Amphiphilic Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization, and Use in Cancer Detection in Vivo

    J. Park, M. K. Yu, Y. Y. Jeong, J. W. Kim, K. Lee, V. N. Phan, S. Jon
    J. Mater. Chem., 2009, 19, 6412
    Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as T2-contrast agents for magnetic resonance imaging (MRI). Herein we develop various antibiofouling amphiphilicpolymer-coated SPIONs using a one-step nanoemulsion m...
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  11. 57. Quantitative Assessment of Nanoparticle Single Crystallinity: Palladium-Catalyzed Splitting of Polycrystalline Metal Oxide Nanoparticles

    H. Kim, M. Lee, Y. Kim, J. Huh, H. Kim, M. Kim, T. Kim, V. N. Phan, S.-W. Lee, Y.-B. Lee, G.-R. Yi, S. Haam, and K. Lee
    Angew. Chem. Int. Ed., 2009, 48, 5129
    Crystal gazing: A simple Pd-catalyzed site-specific nanoetching method was developed to visualize the polycrystalline nature of Fe3O4 (see picture), Fe2O3, MnFe2O4, CoFe2O4, and MnO nanoparticle systems. The technique relies on th...
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  12. 56. Gold layered Calcium Phosphate Plasmonic Resonants for Localized Photothermal treatment of Human Epithelial Cancer

    J. Kang, J. Yang, J. Lee, S. J. Oh, S. Moon, H. J. Lee, S. C. Lee, J.-H. Son, D. Kim, K. Lee, J.-S. Suh, Y.-M. Huh, and S. Haam
    J. Mater. Chem., 2009, 19, 2902
    We fabricated de novo biocompatible mineral plasmon resonants for localized and systemic treatment of cancer. Biodegradable calcium-phosphate gold nanocomposites were synthesized for inducing a superior surface plasmon resonance effe...
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    55. Material and Gas-Sensing Properties of Tungsten Oxide Nanorod Thin-films

    Y. S. Kim and K. Lee
    J. Nanosci. Nanotechno., 2009, 9, 2463 (invited)
    Tungsten oxide thin-films were deposited simply by drop-casting a solution containing singlecrystalline and monodispersed W18O49 nanorods prepared by a large-scale colloidal synthesis route. They were verified to be highly porous,nonstoich...
    Read More
  14. 54. Selective Enrichment of Cysteine-Containing Peptides Using SPDP-Functionalized Superparamagnetic Fe3O4@SiO2 Nanoparticles. Application to Comprehensive Proteomic Profiling

    A. Palani, J.-S. Lee, J. Huh, M. Kim, Y.-J. Lee, K. Lee, and S.-W. Lee
    J. Proteome Res., 2008, 7, 3591
    Superparamagnetic Fe3O4@SiO2 core−shell nanoparticles (ca. 30 nm diameter), which are surface-modified with a thiol-specific functional group, exhibit superb capturing efficiency toward cysteinyl peptides without contamination fro...
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  15. 53. Hollow Silica Nanocontainers as Drug Delivery Vehicles

    J. Yang, J. Lee, J. Kang, K. Lee, J.-S. Suh, H.-G. Yoon, Y.-M. Huh, and S. Haam
    Langmuir, 2008, 24, 3417
    Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by rem...
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  16. 52. Fluorescent Magnetic Nanohybrids as Multimodal Imaging Agents for Human Epithelial Cancer Detection

    J. Yang, E.-K. Lim, H. J. Lee, J. Park, S. C. Lee, K. Lee, H.-G. Yoon, J. -S. Suh, Y.-M. Huh, and S. Haam
    Biomaterials, 2008, 29, 2548
    Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrysta...
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  17. 51. Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications

    J. Yang, J. Lee, J. Kang, H.-J. Ko, K. Lee, J.-S. Suh, H.-G. Yoon, Y.-M. Huh, and S. Haam
    Nanotechnology, 2008, 19, 075610
    We synthesized novel fluorescent magnetic silica nanoparticles (FMSNPs) containing large magnetic components for biomedical application. By employing assemblies of magnetic nanoparticles as kernels against FMSNPs, both the saturat...
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  18. 50. Multifunctional Magnetic Nanoparticles-Gold Nanocomposites: Human Epithelial Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy

    J. Lee, H. Ko, J. Yang, S.-J. Oh, J. Kang, J. Son, K. Lee, S.-W. Lee, J.-S. Suh, H.-G. Yoon, Y.-M. Huh, S. Haam
    Adv. Funct. Mater., 2008, 18, 258
    Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra-sensitive MnFe2O4 m...
    Read More
  19. 49. Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer

    J. Yang, C.-H. Lee, H.-J. Go, J.-S. Suh, H.-G. Yoon, K. Lee, Y.-M. Huh, S. Haam
    Angew. Chem., Int. Ed., 2007, 46, 8836
    Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, and encapsulating amphiphilic block copolymers for...
    Read More
  20. 48. Gadolinium Oxide Nanoring and Nanoplate: Anisotropic Shape Control

    J. Paek, C.-H. Lee, J. Choi, S.-Y. Choi, A. Kim, J. W. Lee, K. Lee
    Crystal Growth & Des., 2007, 7, 1378
    Colloidal cubic Gd2O3 nanorings and nanoplates are selectively prepared from low-temperature (90 °C) hydrolysis of Gd(acac)3 and subsequent in situ thermal dehydration of the hydrolyzed precursor−surfactant aggregates at 320 °C.
    Read More
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    47. Surface-modified Nafion membrane by oleylamine-stabilized Pd nanoparticles for DMFC applications

    A. H. Tian, J.-Y. Kim, J. Y. Shi, K. Kim, K. Lee
    J. Power Sources, 2007, 167, 302
    The surface of Nafion was modified by applying palladium nanoparticles as methanol barrier materials to decrease methanol crossover and improve the performance of fuel cells. The properties of the Pd-modified membrane, in terms of conductivi...
    Read More
  22. 46. V-shaped Tin Oxide Nanostructure Featuring a Broad Photocurrent Signal: An Effective Visible-Light Driven Photocatalyst

    G. Wang, W. Lu, J. Li, J. Choi, Y. Jeong, S.-Y. Choi, J. -B. Park, M. K. Ryu, K. Lee
    Small, 2006, 2, 1436
    A visible difference: SnO2 nanorods and V-shaped bipods with small diameters (<5 nm; see TEM image), high crystallinity, and good solubility in organic solvents have been synthesized. The bipods have high structural stability and a p...
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    45. High Performance of Monodisperse PtRu Nanoalloy on Carbon as a DMFC Catalyst

    Y. H. Lee, G. Lee, J. Shim, S. Hwang, J. Kwak, K. Lee, H. Song, J. T. Park
    Chem. Mater., 2006, 18, 4209
    The highly monodisperse PtRu (1:1) colloidal nanoalloy was prepared by the co-reduction of Pt(acac)2 and Ru(acac)3 precursors, deposited on a Vulcan carbon (Vc) support and subsequently treated by acetic acid to generate active PtRu/Vc catal...
    Read More
  24. 44. Ambient Pressure Synthesis of Size-Controlled Corundum-Type In2O3 Nanocubes

    C. H. Lee, M. Kim, T, Kim, A, Kim, J. Paek, J. W. Lee, S.-Y. Choi, K. Kim, J. -B. Park, and K. Lee
    J. Am. Chem. Soc., 2006, 128, 9326
    Hydrolysis of In(O-iPr)3 by 10 molar excess of water at 90 °C in a surfactant/solvent mixture of oleylamine/oleic acid/trioctylamine provides very small nanoparticles (<5 nm in diameter) of In(O)(OH). Subsequent in situ thermolysis o...
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    43. Li-driven Electrochemical Properties of WO3 Nanorods

    . Wang, Z, Wen, Y. Jeong, J. Choi, K. Lee, J. Li
    Nanotechnolgy, 2006, 17, 3116
    The Li-driven electrochemical properties of monoclinic WO3 nanorods, which are prepared by a solution-based colloidal approach, have been studied, and the relationship between the properties and the nanostructures of the material has been es...
    Read More
  26. 42. Immobilization of histidine-tagged proteins by magnetic nanoparticles encapsulated with nitrilotriacetic acid (NTA)-phospholipids micelle

    Y. T. Lim, K. Y. Lee, K. Lee, and B. Y. Chung
    Biochem. Bioph. Res. Co., 2006, 344, 926
    We described the development of functionalized magnetic nanoparticles (MNPs) with PEG-modification, a phospholipids micelle coating, and their use in manipulating histidine-tagged proteins. Highly monodisperse MNPs were synthesized i...
    Read More
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    41. Highly Efficient MCM-48-based Template Synthesis of Osmium and Platinum 3-D Nanonetworks

    C. H. Lee, K. Lee, S. B. Chang, J. T. Park, B. Kim
    Bull. Korean Chem. Soc., 2006, 27, 130
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    40. Enrichment of N-terminal Sulfonated Peptides by a Water-Soluble Fullerene Derivative and its Application to Highly Efficient Proteomics

    Y. H. Lee, J.-W. Lee, S. Ryu, S.-W. Lee, C. H. Lee, and K. Lee
    Anal. Chim. Acta., 2006, 556, 140
    Recent studies have shown that N-terminal sulfonation of tryptic peptides by various sulfonating molecules greatly improves their post-source decay processes (e.g., in matrix-assisted laser desorption ionization) or the gas phase fragmentati...
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