098. Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging.

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author E.-K. Lim, B. Kang, Y. Choi, E. Jang, S. Han, K. Lee, J.-S. Suh, S. Haam, Y.-M. Huh
journal Nanotechnology, 2014, 25, 245103
Link http://iopscience.iop.org/article/10.108...ld.iop.org
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We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

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    For the application of gadolinium oxide (Gd2O3) nanoparticles as terahertz contrast agents, their optical properties in a solvent were studied using terahertz time-domain spectroscopy. The power absorption and refractive index of the samples...
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  54. 069. Molecular imaging with terahertz waves

    S. J. Oh, J. Choi, I. Maeng, J. Y. Park, K. Lee, Y.-M. Huh , J.-S. Suh, S. Haam, J.-H. Son
    Opt. Express, 2011, 19, 4009
    We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivoimages of cancers. This technique can detect qua...
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  55. 068. Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

    J. Yang, J. Choi, D. Bang, E. Kim, E.-K. Lim, H. Park, J.-S. Suh, K. Lee, K.-H. Yoo, E.-K. Kim,Y.-M. Huh, S. Haam
    Angew. Chem. Int. Ed., 2011, 50, 441
    Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted t...
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